Very cool post.. this could be a real game-changer if the signal holds up. The review + early human data on GLP-1 receptor agonists are compelling: beyond metabolic effects, GLP-1R activation seems to modulate core reward circuits (dopamine, GABA, etc.) linked to craving and addiction. At the same time, i would prefer a bit more caution i.e. reality check. Most of the data are still preclinical or from small/short Phase 2 trials; we need larger, longer, and more diverse studies to know who benefits, at what dose, and what the safety/side-effect profile looks like when used for ASUD.
My personal experience (i was a rather heavy drinker for decades) is not that you quit drinking, but you simply don't want to drink a lot. 2 glasses of wine and you don't want more.
A few times in a company of friends i felt compelled to have a 3rd glass but i could never finish it - not that it felt disgusting, or felt too drunk (i practically stopped feeling any effects from alcohol at all, at least not in amounts that i can drink), but i had a weird feeling much akin to being overly full with food. Like, i just didn't want any more of it.
So in practice, you quit drinking completely - in 2 years that i've been on Wegovy, i've never been even tipsy once, let alone drunk.
As expected, it had negative social consequences, i lost a lot of contacts and had a hard time building new ones, so i feel more lonely than before, but of course, the benefits of quitting drinking - especially without making any effort for this, or even trying - are more than worth it.
Appreciate the comment!! Even if just anecdotally - you mention loneliness etc. - did you experience any negative (particularly emotional) side effects?
Very cool post.. this could be a real game-changer if the signal holds up. The review + early human data on GLP-1 receptor agonists are compelling: beyond metabolic effects, GLP-1R activation seems to modulate core reward circuits (dopamine, GABA, etc.) linked to craving and addiction. At the same time, i would prefer a bit more caution i.e. reality check. Most of the data are still preclinical or from small/short Phase 2 trials; we need larger, longer, and more diverse studies to know who benefits, at what dose, and what the safety/side-effect profile looks like when used for ASUD.
My personal experience (i was a rather heavy drinker for decades) is not that you quit drinking, but you simply don't want to drink a lot. 2 glasses of wine and you don't want more.
A few times in a company of friends i felt compelled to have a 3rd glass but i could never finish it - not that it felt disgusting, or felt too drunk (i practically stopped feeling any effects from alcohol at all, at least not in amounts that i can drink), but i had a weird feeling much akin to being overly full with food. Like, i just didn't want any more of it.
So in practice, you quit drinking completely - in 2 years that i've been on Wegovy, i've never been even tipsy once, let alone drunk.
As expected, it had negative social consequences, i lost a lot of contacts and had a hard time building new ones, so i feel more lonely than before, but of course, the benefits of quitting drinking - especially without making any effort for this, or even trying - are more than worth it.
Appreciate the comment!! Even if just anecdotally - you mention loneliness etc. - did you experience any negative (particularly emotional) side effects?